Association of SCN5A gene polymorphism with dilated cardiomyopathy

Subjects and methods. The study included patients with IDC (group 1; n=111, 89.2% men, average age 51.7±9.7 years) ICM 2; n=110, 91.5% 58.7±8.4 years). All (IDC ICM) underwent coronary angiography. Based on the anamnesis data instrumental studies, those who could be said to have no risk factors for development of dilatation heart cavities were identified in group 1. And reliably diagnosed artery disease 2, that is, is due a previous myocardial infarction, existing angina pectoris. control (n=121, 53.6±4.8 had manifestations cardiovascular diseases. laboratory as well molecular genetic studies A/G polymorphism SCN5A gene (rs1805124). Results. In 51.4% carriers common homozygous AA genotype, heterozygous AG genotype-40.5%, rare GG genotype-8.1%. 63.3% genotype by allele, 33.5% allele – 3.2%. analysis revealed statistically significant decrease frequency carrying compared rs1805124 gene. ICM, А (69.5% vs. 80.1%, p=0.003) (50.9% 63.3%, p=0.030) significantly less than group. was statically more (11.8% 3.2%, p=0.004). Also, G detected often (30.5% 19.9%, p= 0.003). Conclusion. polymorphic locus associated both ICM. Homozygous A are conditionally protective these conditions men.